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Tacrolimus (FK506)

Tacrolimus (FK506)

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Product Code: 3228
Availability: In Stock
$108.00
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FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.

Chemical Name:
2-[(1-Methylpropyl)dithio]-1H-imidazole

Inhibitors Others Others Tacrolimus (FK506) 104987-11-3
Biological Activity:
Biological Activity FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.
Technical Data:
M.W. 804.02
Formula: C<sub>44</sub>H<sub>69</sub>NO<sub>12</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 104987-11-3
References:
References Flanagan WM, et al. Nature, 1991, 352(6338), 803-807. O'Keefe SJ, et al. Nature, 1992, 357(6380), 692-694. Fruman DA, et al. Proc Natl Acad Sci U S A, 1992, 89(9), 3686-3690. Wiederrecht G, et al. Ann N Y Acad Sci, 1993, 696, 9-19. Muthuraman A, et al. J Brachial Plex Peripher Nerve Inj, 2010, 5, 13.

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