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Odanacatib (MK-0822)

Odanacatib (MK-0822)

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Product Code: 3328
Availability: In Stock
$587.00
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Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.

Chemical Name Pentanamide, N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-, (2S)-

Inhibitors Others Cathepsin K Odanacatib (MK-0822) 603139-19-1
Biological Activity:
Biological Activity Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.
Technical Data:
M.W. 525.56
Formula: <p>C<sub>25</sub>H<sub>27</sub>F<sub>4</sub>N<sub>3</sub>O<sub>3</sub>S</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 603139-19-1
References:
References Gauthier JY, et al. Bioorg Med Chem Lett. 2008, 18(3), 923-928. Leung P, et al. Bone. 2011, 49(4), 623-635. Pennypacker BL, et al. J Bone Miner Res. 2011, 26(2):252-262. Masarachia PJ, et al. J Bone Miner Res. 2012, 27(3), 509-523.

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