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SB705498

SB705498

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Product Code: 3257
Availability: In Stock
$461.00
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SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.

Chemical Name:
(R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea

Inhibitors Others TRPV SB705498 501951-42-4
Biological Activity:
Biological Activity SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.
Technical Data:
M.W. 429.23
Formula: C<sub>17</sub>H<sub>16</sub>BrF<sub>3</sub>N<sub>4</sub>O
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 501951-42-4
References:
References Gunthorpe MJ, et al. J Pharmacol Exp Ther. 2007, 321(3), 1183-1192. Rami HK, et al. Bioorg Med Chem Lett. 2006, 16(12), 3287-3291.

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