A-674563

A-674563

Product Code: 3438
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A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.

Chemical Name: (2S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine

Biological Activity:
Biological Activity A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
Technical Data:
M.W. 358.44
Formula:

C22H22N4O

Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 552325-73-2
References:
References Luo Y, et al, Mol Cancer Ther, 2005, 4(6), 977-986. Zhu QS, et al, Cancer Res, 2008, 68(8), 2895-2903. Tatsuya Okuzumi, et al, Mol Biosyst, 2010, 6(8), 1389-1402.

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