Lipoprotein Lipase Activator, NO-1886

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Product Code: 9780
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An inducer of lipoprotein lipase mRNA.

Chemical Name: Diethyl {4-[(4-bromo-2-cyanophenyl)carbamoyl]benzyl}phosphonate

Biological Activity:
Biological Activity	Lipoprotein Lipase Activator is a cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARα or PPARγ agonistic activities. Lipoprotein Lipase Activator lowers serum lipid levels and plasma triglycerides with concomitant elevation in high-density lipoprotein cholesterol (HDL-C) in animal models. Lipoprotein Lipase Activator also induces fatty acid oxidation related enzymes, lowers free fatty acids (FFA), and minimizes fat accumulation. Also reported to suppress the plasma levels of TNF-a and COX-2 and displays anti-tumor properties.
Technical Data:
M.W.	451.3
Formula:	C<sub><sup>19</sup></sub>H<sub>20</sub>BrN<sub>2</sub>O<sub>4</sub>
Solubility:	Soluble in DMSO (≥20 mg/ml).
Storage:	Store at -4 C
CAS No:	133208-93-2
References:
References	Niho, N., et al. 2005. Proc, Natl. Acad. Sci. USA 102, 2970. Yin, W., et al. 2004. Pharmacol. Res. 49, 199. Doi, M., et al. 2003. Metabolism 52, 1547. Kusunoki, M., et al. 2000. Diabetologia 43, 875. Tsutsmi, K., et al. 1993. J. Clin. Invest. 92, 411.

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