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H 89 2HCl

H 89 2HCl

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Product Code: 3173
Availability: In Stock
$108.00
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H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II.

Chemical Name :

(E)-N-(2-(4-bromocinnamylamino)ethyl)isoquinoline-5-sulfonamide dihydrochloride

Inhibitors Others PKA H 89 2HCl 130964-39-5
Biological Activity:
Biological Activity H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II.
Technical Data:
M.W. 519.28
Formula: C<sub>20</sub>H<sub>20</sub>BrN<sub>3</sub>O<sub>2</sub>S.2HCl
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 130964-39-5
References:
References Chijiwa T, et al. J Biol Chem., 1990, 265(9), 5267-5272. Davies SP, et al. Biochem J, 2000, 351(Pt 1), 95-105. Lochner A, et al. Cardiovasc Drug Rev, 2006, 24(3-4), 261-274. Murray AJ. Sci Signal, 2008, 1(22), re4 Davis MA, et al. J Pharmacol Exp Ther, 2006, 318(2), 589-595.

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