TX-1918

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Product Code: 9786
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A potent inhibitor for eEF2K

Chemical Name: 2-((3,5-dimethyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione

Biological Activity:
Biological Activity	TX-1918 may be useful as a therapeutic agent for cancer treatment in animal models. A cell-permeable arylidene-cyclopentenedione derived tyrphostin that acts as a potent inhibitor for eukaryotic elongation factor-2 kinase (eEF2K, IC50 = 440 nM). At higher concentrations, TX-1918 has been shown to inhibit other kinases, including proto-oncogene tyrosine-protein kinase Src (c-SRC, IC50 = 4.4 μM), protein kinase A and C (PKA and PKC, IC50 = 44 μM for each), and epidermal growth factor receptor kinase (EGFR-K, IC50 = 440 μM).
Technical Data:
M.W.	228.2
Formula:	C<sub>14</sub>H<sub>12</sub>O<sub>3</sub>
Solubility:	Soluble in DMSO (10 mg/ml).
Storage:	Store at 4° C
CAS No:	503473-32-3
References:
References	Hori, Hitoshi., et al., 2002. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorganic & medicinal chemistry. 10(10): 3257-65. PMID: 12150871

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