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Ataluren (PTC124)

Ataluren (PTC124)

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Product Code: 3036
Availability: In Stock
$89.00
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PTC124 (Ataluren) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.

Chemical Name: 3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid

Inhibitors Transmembrane Transporters CFTR Ataluren (PTC124) 775304-57-9
Biological Activity:
Biological Activity PTC124 (Ataluren) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.
Technical Data:
M.W. 284.24
Formula: C<sub>15</sub>H<sub>9</sub>FN<sub>2</sub>O<sub>3</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 775304-57-9
References:
References Welch EM, et al. Nature, 2007, 447(7140), 87-91. Du M, et al. Proc Natl Acad Sci U S A, 2008, 105(6), 2064-2069.

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