VX-809 (Lumacaftor)

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Product Code: 3183
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$398.00

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VX-809 acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM. Phase 3.

Chemical Name:
3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid

Biological Activity:
Biological Activity	VX-809 acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM. Phase 3.
Technical Data:
M.W.	452.41
Formula:	C<sub>24</sub>H<sub>18</sub>F<sub>2</sub>N<sub>2</sub>O<sub>5</sub>
Solubility:	DMSO
Purity:	98%
CAS No:	936727-05-8
References:
References	Van Goor F, et al. Proc Natl Acad Sci U S A, 2011, 108(46), 18843-18848.

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