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BI-D1870

BI-D1870

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Product Code: 3064
Availability: In Stock
$335.00
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BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.

Chemical Name: 6(5H)-Pteridinone, 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-

Inhibitors PI3K/Akt/mTOR S6 Kinase BI-D1870 501437-28-1
Biological Activity:
Biological Activity BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B.
Technical Data:
M.W. 391.42
Formula: C<sub>19</sub>H<sub>23</sub>F<sub>2</sub>N<sub>5</sub>O<sub>2</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 501437-28-1
References:
References GP Sapkota, et al. Biochem J, 2007, 401(Pt 1), 29–38.

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