Lonafarnib

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Product Code: 3397
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Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Phase 3.

Chemical Name: 1-Piperidinecarboxamide, 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-

Biological Activity:
Biological Activity	Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Phase 3.
Technical Data:
M.W.	638.82
Formula:	<p>C<sub>27</sub>H<sub>31</sub>Br<sub>2</sub>ClN<sub>4</sub>O<sub>2</sub></p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	193275-84-2
References:
References	Liu M, et al. Cancer Res, 1998, 58(21), 4947-4956. Chun KH, et al. Cancer Res, 2003, 63(16), 4796-4800. Feldkamp MM, et al. Cancer Res, 2001, 61(11), 4425-4431. Sun SY, et al. J Biol Chem, 2007, 282(26), 18800-18809.

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