Valproic acid sodium salt

Valproic acid sodium salt

Product Code: 3198
Availability: In Stock

Valproic acid sodium salt (Sodium valproate) is a HDACinhibitor with IC50 of 0.4 mM and also inhibits GABA-transaminase or succinic semialdehyde dehydrogenase.

Chemical Name:
sodium 2-propylpentanoate

Biological Activity:
Biological Activity Valproic acid sodium salt (Sodium valproate) is a histone deacetylase inhibitor with an IC50 of 0.4 mM and exhibits anticancer, anti-inflammatory and neuroprotective effects. Sodium valproate (VPA) can inhibit the proliferation of tumor cells by inducing G0/G1 phase arrest and cell apoptosis. It displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer’s disease. It also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. It enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2.
Technical Data:
M.W. 166.19
Formula: C<sub>8</sub>H<sub>15</sub>NaO<sub>2</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1069-66-5

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