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BX-795

BX-795

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Product Code: 3080
Availability: In Stock
$184.00
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BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

Chemical Name N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide

Inhibitors PI3K/Akt/mTOR PDK-1 BX795 702675-74-9
Biological Activity:
Biological Activity BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.
Technical Data:
M.W. 591.47
Formula: <p>C<sub>23</sub>H<sub>26</sub>IN<sub>7</sub>O<sub>2</sub>S</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 702675-74-9
References:
References Feldman RI, et al. J Biol Chem. 2005, 280(20), 19867-19874. Clark K, et al. J Biol Chem. 2009, 284(21), 14136-14146. Dangelmaier C, et al. Thromb Haemost. 2013,111(4).

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