Ganetespib (STA-9090)

Ganetespib (STA-9090)

Product Code: 3151
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Ganetespib is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474.

Chemical Name :

5-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2H-1,2,4-triazol-3(4H)-one

Biological Activity:
Biological Activity Ganetespib is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells, induces apoptosis of OSA cells while normal osteoblasts are not affected; active metabolite of STA-1474.
Technical Data:
M.W. 364.4
Formula: C20H20N4O3
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 888216-25-9
References:
References McCleese Jk, et al. Int J Cancer. 2009, 125(12), 2792-2801. Wang Y, et al. Curr Opin Investig Drugs. 2010 , 11(12), 1466-1476. Ying W, et al. Mol Cancer Ther. 2012, 11(2), 475-484. Lin TY, et al. Exp Hematol. 2008, 36(10), 1266-1277.

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