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Semagacestat

Semagacestat

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Product Code: 3260
Availability: In Stock
$398.00
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Semagacestat (LY450139) is a γ-secretase blocker forAβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM. Phase 3.

Chemical Name:
(S)-2-hydroxy-3-methyl-N-((S)-1-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-1-oxopropan-2-yl)butanamide
 

Inhibitors Stem Cells & Wnt Gamma-secretase Semagacestat 425386-60-3
Biological Activity:
Biological Activity Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM. Phase 3.
Technical Data:
M.W. 361.44
Formula: C<sub>19</sub>H<sub>27</sub>N<sub>3</sub>O<sub>4</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 425386-60-3
References:
References Mitani Y, et al. J Neurosci, 2012, 32(6), 2037-2050. Elvang AB, et al. J Neurochem, 2009, 110(5), 1377-1387.

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