LY2109761

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Product Code: 3390
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LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with K_i of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.

Chemical Name: 7-(2-morpholinoethoxy)-4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline

Biological Activity:
Biological Activity	LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.
Technical Data:
M.W.	441.52
Formula:	<p>C<sub>26</sub>H<sub>27</sub>N<sub>5</sub>O<sub>2</sub></p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	700874-71-1
References:
References	Melisi D, et al. Mol Cancer Ther, 2008, 7(4), 829-840. Fransvea E, et al. Hepatology, 2008, 47(5), 1557-1566. Zhang M, et al. Cancer Res, 2011, 71(23), 7155-7167.

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LY2109761

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