Cabozantinib (XL184, BMS-907351)

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Product Code: 3085
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Multi-target kinase inhibitor, inhibits c-Met, VEGFR2, and RET

Chemical Name:

N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Biological Activity:
Biological Activity	Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
Technical Data:
M.W.	501.51
Formula:	<p>C<sub>28</sub>H<sub>24</sub>FN<sub>3</sub>O<sub>5</sub></p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	849217-68-1
References:
References	You WK, et al. Cancer Res, 2011, 71(14), 4758-4768. Torres KE, et al. Clin Cancer Res, 2011, 17(12), 3943-3955. Yakes FM, et al. Mol Cancer Ther, 2011, 10(12), 2298-2308.

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