Cabozantinib (XL184, BMS-907351)

Cabozantinib (XL184, BMS-907351)

Product Code: 3085
Availability: In Stock
$0.00
-+
Bulk Inquiry

Multi-target kinase inhibitor, inhibits c-Met, VEGFR2, and RET

Chemical Name:

N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Biological Activity:
Biological Activity Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
Technical Data:
M.W. 501.51
Formula:

C28H24FN3O5

Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 849217-68-1
References:
References You WK, et al. Cancer Res, 2011, 71(14), 4758-4768. Torres KE, et al. Clin Cancer Res, 2011, 17(12), 3943-3955. Yakes FM, et al. Mol Cancer Ther, 2011, 10(12), 2298-2308.

Write a review

Note: HTML is not translated!
    Bad           Good
Powered By Nsoft Solutions
HDH PHARMA © 2017