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Y-27632 2HCl

Y-27632 2HCl

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Product Code: 3179
Availability: In Stock
$209.00
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Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

Chemical Name:
2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
 

Inhibitors TGF-beta/Smad ROCK Y-27632 2HCl 129830-38-2
Biological Activity:
Biological Activity Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK
Technical Data:
M.W. 320.26
Formula: C<sub>14</sub>H<sub>21</sub>N<sub>3</sub>O.2HCl
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 129830-38-2
References:
References Uehata M, et al. Nature, 1997, 389(6654), 990-994. Itoh K, et al. Nat Med, 1999, 5(2), 221-225. Bito H, et al. Neuron, 2000, 26(2), 431-441. Watanabe K, et al. Nat Biotechnol, 2007, 25(6), 681-686. Hyvelin JM, et al. Circ Res, 2005, 97(2), 185-191. Ishizaki T, et al. Mol Pharmacol. 2000, 57(5), 976-983.

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