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LDN-193189

LDN-193189

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Product Code: 3401
Availability: In Stock
$713.00
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LDN193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.

Chemical Name 4-[6-(4-Piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride

Inhibitors Stem Cells & Wnt TGF-beta/Smad LDN193189 1062368-62-0
Biological Activity:
Biological Activity LDN193189 HCl is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, 200-fold selectivity for BMP versus TGF-β.
Technical Data:
M.W. 442.94
Formula: <p>C<sub>25</sub>H<sub>22</sub>N<sub>6</sub>.HCl</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1062368-62-0
References:
References Yu PB, et al. Nat Med, 2008, 14(12), 1363-1369. Cannon JE, et al. Br J Pharmacol, 2010, 161(1), 140-149. Lee YC, et al. Cancer Res, 2011, 71(15), 5194-5203. Derwall M, et al. Arterioscler Thromb Vasc Biol, 2012, 32(3), 613-622.

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