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NSC 23766

NSC 23766

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Product Code: 3342
Availability: In Stock
$133.00
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NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.

Chemical Name N6-[2-[[4-(Diethylamino)-1-methylbu-tyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-qu-inolinediamine trihydrochloride

Inhibitors Cell Cycle Rho NSC 23766 1177865-17-6
Biological Activity:
Biological Activity NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.
Technical Data:
M.W. 530.96
Formula: C24H35N7.3HCl
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1177865-17-6
References:
References Gao Y, et al. Proc Natl Acad Sci U S A, 2004, 101(20), 7618-7623. Akbar H, et al. Methods Enzymol, 2006, 406, 554-565. Désiré L, et al. J Biol Chem, 2005, 280(45), 37516-3 Sawada N, et al. Circ Res, 2008, 103(4), 360-368. Yoshida T, et al. Mol Cancer Ther, 2010, 9(6), 1657-1668. Yao HY, et al. Biochim Biophys Acta, 2011, 1810(7):666-674.

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