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Palbociclib

Palbociclib

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Product Code: 3319
Availability: In Stock
$209.00
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PD0332991 is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 2/3.

Chemical Name Ethanesulfonic acid, 2-hydroxy-, compd. with 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one (1:1)

Inhibitors Cell Cycle CDK Palbociclib 827022-33-3
Biological Activity:
Biological Activity Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 2/3.
Technical Data:
M.W. 573.66
Formula: <p>C<sub>24</sub>H<sub>29</sub>N<sub>7</sub>O<sub>2</sub>.C<sub>2</sub>H<sub>6</sub>O<sub>4</sub>S</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 827022-33-3
References:
References Fry DW, et al. Mol Cancer Ther, 2004, 3(11), 1427-1438. Baughn LB, et al. Cancer Res, 2006, 66(15), 7661-7667. Finn RS, et al. Breast Cancer Res, 2009, 11(5), R77. Fry DW, et al. J Biol Chem, 2001, 276(20), 16617-16623.

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