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Ruxolitinib

Ruxolitinib

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Product Code: 3270
Availability: In Stock
$284.00
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INCB018424 is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.

Chemical Name:
(3R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Inhibitors Stem Cells & Wnt JAK Ruxolitinib 941678-49-5
Biological Activity:
Biological Activity INCB018424 is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.
Technical Data:
M.W. 306.37
Formula: C<sub>17</sub>H<sub>18</sub>N<sub>6</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 941678-49-5
References:
References Quintas-Cardama A, et al. Blood, 2010, 115(15), 3109-3117. Verstovsek S, et al. N Engl J Med, 2012, 366(9), 799-807. Harrison C, et al. N Engl J Med, 2012, 366(9), 787-798.

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