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NVP-BHG712

NVP-BHG712

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Product Code: 3327
Availability: In Stock
$398.00
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NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.

Chemical Name 4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide

Inhibitors Protein Tyrosine Kinase Ephrin receptor NVP-BHG712 940310-85-0
Biological Activity:
Biological Activity NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.
Technical Data:
M.W. 503.48
Formula: <p>C<sub>26</sub>H<sub>20</sub>F<sub>3</sub>N<sub>7</sub>O</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 940310-85-0
References:
References Martiny-Baron G, et al. Angiogenesis. 2010, 13(3), 259-267.

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