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Dolutegravir (GSK1349572)

Dolutegravir (GSK1349572)

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Product Code: 3120
Availability: In Stock
$461.00
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S/GSK1349572 (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. Phase 3.

Chemical Name

2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)-

Inhibitors Microbiology Integrase Dolutegravir (GSK1349572) 1051375-16-6
Biological Activity:
Biological Activity S/GSK1349572 (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. Phase 3.
Technical Data:
M.W. 419.38
Formula: C<sub>20</sub>H<sub>19</sub>F<sub>2</sub>N<sub>3</sub>O<sub>5</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1051375-16-6
References:
References Vézinet F, et al. AIDS. 2010, 24(17), 2753-275 Kobayashi M, et al. Antimicrob Agents Chemother. 2011, 55(2), 813-821.

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