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OSI-906

OSI-906

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Product Code: 3336
Availability: In Stock
$335.00
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OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R with IC50 of 35 nM; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3.

Chemical Name (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol

Inhibitors Protein Tyrosine Kinase IGF-1R OSI-906 867160-71-2
Biological Activity:
Biological Activity OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R with IC50 of 35 nM; modestly potent to InsR with IC50 of 75 nM, and no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc. Phase 3.
Technical Data:
M.W. 421.49
Formula: <p>C<sub>26</sub>H<sub>23</sub>N<sub>5</sub>O</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 867160-71-2
References:
References Mulvihill MJ, et al. Future Med Chem, 2009, 1(6), 1153-1171. McKinley ET, et al. Clin Cancer Res, 2011, 17(10), 3332-3340.

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