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Doxorubicin

Doxorubicin

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Product Code: 3124
Availability: In Stock
$108.00
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Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.

Chemical Name:

(8S,10S)-10-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

Inhibitors DNA Damage Topoisomerase Doxorubicin 25316-40-9
Biological Activity:
Biological Activity Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.
Technical Data:
M.W. 579.98
Formula: C<sub>27</sub>H<sub>29</sub>NO<sub>11</sub>.HCl
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 25316-40-9
References:
References Sun W, et al. Cancer Res, 2009, 69(10), 4294-4300. Granados-Principal S, et al. Food Chem Toxicol, 2010, 48(6), 1425-1438. de Luca A, et al. Biochem J, 2011, 440(2), 175-183. Cheriyath V, et al. Br J Cancer, 2011, 104(6), 957-967. Zimmermann M, et al. J Biol Chem, 2012, 287(27), 22838-22853. Wang S, et al. J Biol Chem, 2012, 287(11), 8001-8012. Luke JJ, et al. Clin Cancer Res, 2012, 18(9), 2638-2647. Mandili G, et al. FEBS J, 2012, 279(12), 2182-2191.

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