Entinostat

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Product Code: 3132
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Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10. Phase 1/2.

Chemical Name: pyridin-3-ylmethyl 4-((2-aminophenyl)carbamoyl)benzylcarbamate

Biological Activity:
Biological Activity	Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10. Phase 1/2.
Technical Data:
M.W.	376.41
Formula:	C<sub>21</sub>H<sub>20</sub>N<sub>4</sub>O<sub>3</sub>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	209783-80-2
References:
References	Saito A, et al. Proc Natl Acad Sci U S A, 1999, 96(8), 4592-4597. Sugawara T, et al. 95th AACR, Orlando, 2004, Abst#2451 Rosato RR, et al. Cancer Res, 2003, 63(13), 3637-3645. Zhang ZY, et al. Neurosci, 2010, 169, 370-377. Kato Y, Clin Cancer Res, 2007, 13(15), 4538-4546. Wegener D, et al. Chem Biol, 2003, 10(1), 61-68.

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