SB-431542

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Product Code: 9778
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SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.

Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

Biological Activity:
Biological Activity	SB 431542 is a small molecule that acts as a specific and selective inhibitor of TGFβ RI, ACTR-IB and ACTR-IC (transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, 5, and 7). Renal carcinoma studies have demonstrated that SB 431542 is a selective inhibitor of Smad3 phosphorylation (IC50= 94nM) and TGF-β-1 collagen induced lα1 (col Iα1).
Technical Data:
M.W.	384.39
Formula:	C22H16N4O3
Solubility:	Soluble in DMSO (77 mg/ml at 25 °C), ethanol (45 mg/ml at 25 °C)
Storage:	Store at -20° C
CAS No:	301836-41-9
References:
References	1. Laping, N.J., et al. 2002. Mol. Pharmacol. 62: 58-64. PMID: 12065755 2. Inman, G.J., et al. 2002. Mol. Pharmacol. 62: 65-74. PMID: 12065756 3. Matsuyama, S., et al. 2003. Cancer Res. 63: 7791-7798. PMID: 14633705 4. Hjelmeland, M.D., et al. 2004. Mol. Cancer Ther. 3: 737-745. PMID: 15210860

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