GSK461364

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Product Code: 3163
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$473.00

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GSK461364 inhibits purified Plk1 with K_i of 2.2 nM. It is more than 1000-fold selective against Plk2/3. Phase 1.

Chemical Name : 5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-((R)-1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide

Biological Activity:
Biological Activity	GSK461364 inhibits purified Plk1 with Ki of 2.2 nM. It is more than 1000-fold selective against Plk2/3. Phase 1.
Technical Data:
M.W.	543.6
Formula:	C<sub>27</sub>H<sub>28</sub>F<sub>3</sub>N<sub>5</sub>O<sub>2</sub>S
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	929095-18-1
References:
References	Gilmartin AG, et al. Cancer Res, 2009, 69(17), 6969-6977. Degenhardt Y, et al. Mol Cancer Ther, 2010, 9(7), 2079-2089. Olmos D, et al. Clin Cancer Res, 2011, 17(10), 3420-3430.

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