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AUY922

AUY922

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Product Code: 3039
Availability: In Stock
$335.00
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AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 1/2.

Chemical Name: 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide

Inhibitors Cytoskeletal Signaling HSP (e.g. HSP90) AUY922 747412-49-3
Biological Activity:
Biological Activity AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 1/2.
Technical Data:
M.W. 465.54
Formula: C<sub>26</sub>H<sub>31</sub>N<sub>3</sub>O<sub>5</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 747412-49-3
References:
References Lee KH, et al. Cancer Sci, 2011, 102(7), 1388-1395. Okui T, et al. Anticancer Res, 2011, 31(4), 1197-1204. Eccles SA, et al. Cancer Res, 2008, 68(8), 2850-2860.

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