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PF-562271

PF-562271

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Product Code: 3357
Availability: In Stock
$335.00
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PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

Chemical Name Methanesulfonamide, N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methyl-

Inhibitors Cytoskeletal Signaling FAK PF-562271 717907-75-0
Biological Activity:
Biological Activity PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
Technical Data:
M.W. 507.49
Formula: <p>C<sub>21</sub>H<sub>20</sub>F<sub>3</sub>N<sub>7</sub>O<sub>3</sub>S</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 717907-75-0
References:
References Roberts WG, et al. Cancer Res, 2008, 68(6), 1935-1944. Lim ST, et al. Cell Cycle, 2008, 7(15), 2306-2314. Canel M, et al. Cancer Res, 2010, 70(22), 9413-9422. Sun H, et al. Cancer Biol Ther, 2010, 10(1), 38-43. Bagi CM, et al. Cancer, 2008, 112(10), 2313-2321.

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