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Imatinib Mesylate

Imatinib Mesylate

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Product Code: 3427
Availability: In Stock
$180.00
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Imatinib Mesylate (STI571) is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

Chemical Name N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide methanesulfonic acid

Inhibitors Angiogenesis Bcr-AbI Imatinib Mesylate 220127-57-1
Biological Activity:
Biological Activity Imatinib Mesylate (STI571) is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
Technical Data:
M.W. 589.71
Formula: <p>C<sub>29</sub>H<sub>31</sub>N<sub>7</sub>O.CH<sub>4</sub>SO<sub>3</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 220127-57-1
References:
References Buchdunger E, et al. Proc Natl Acad Sci USA, 1995, 92(7), 2558–2562. Heinrich MC, et al. Blood. 2000, 96(3), 925-932. Yao JC, et al. Clin Cancer Res. 2007, 13(1), 234-240. Zheng F, et al. Med Oncol, 2012, 29(3), 2127-2135. Decaudin D, et al. Int J Cancer. 2005, 113(5), 849-856. Ballinger ML, et al. J Cell Mol Med. 2010,14(6B), 1408-1418.

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