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Ponatinib

Ponatinib

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Product Code: 3305
Availability: In Stock
$133.00
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Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.

Chemical Name 3-(2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

Inhibitors Cytoskeletal Signaling Bcr-Abl Ponatinib 943319-70-8
Biological Activity:
Biological Activity Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.
Technical Data:
M.W. 532.56
Formula: <p>C<sub>29</sub>H<sub>27</sub>F<sub>3</sub>N<sub>6</sub>O</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 943319-70-8
References:
References O'Hare T, et al. Cancer Cell, 2009, 16(5), 401-412. Huang WS, et al. J Med Chem, 2010, 53(12), 4701-4719. Gozgit JM, et al. Mol Cancer Ther, 2011, 10(6), 1028-1035. Gozgit JM, et al. Mol Cancer Ther, 2012, doi: 10.1158/1535-7163. [Epub ahead of print] O'Hare T, et al. Blood, 2004, 104(8), 2532-2539.

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