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ICG-001

ICG-001

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Product Code: 3430
Availability: In Stock
$587.00
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ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.

Chemical Name (6S,9aS)-6-(4-hydroxybenzyl)-N-benzyl-8-(naphthalen-1-ylmethyl)-4,7-dioxo-hexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

Inhibitors Cytoskeletal Signaling Wnt/beta-catenin ICG-001 780757-88-2
Biological Activity:
Biological Activity ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
Technical Data:
M.W. 548.63
Formula: <p>C<sub>33</sub>H<sub>32</sub>N<sub>4</sub>O<sub>4</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 780757-88-2
References:
References Emami KH, et al, Proc Natl Acad Sci USA, 2004, 101(34), 12682-12687. Teo JL, et al, Proc Natl Acad Sci USA, 2005，102（34），12171-12176. Yan D, et al, J Biol Chem, 2012, 287(11), 8598-8612. Henderson WR Jr, et al, Proc Natl Acad Sci USA, 2010, 107(32), 14309-14314.

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