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XAV-939

XAV-939

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Product Code: 3181
Availability: In Stock
$83.00
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XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM, regulates axin levels and does not affect CRE, NF-κB or TGF-β.

Chemical Name:
2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol

Inhibitors Cytoskeletal Signaling Wnt/beta-catenin XAV-939 284028-89-3
Biological Activity:
Biological Activity XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM, regulates axin levels and does not affect CRE, NF-κB or TGF-β.
Technical Data:
M.W. 312.31
Formula: C<sub>14</sub>H<sub>11</sub>F<sub>3</sub>N<sub>2</sub>OS
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 284028-89-3
References:
References Dregalla RC, et al. Aging, 2010, 2(10), 691-708. Huang SM, et al. Nature, 2009, 461(7264), 614-620.

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