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MK-2206 2HCl

MK-2206 2HCl

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Product Code: 3378
Availability: In Stock
$209.00
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MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.

Chemical Name 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one

Inhibitors Cytoskeletal Signaling Akt MK-2206 2HCl 1032350-13-2
Biological Activity:
Biological Activity MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2.
Technical Data:
M.W. 480.39
Formula: <p>C<sub>25</sub>H<sub>21</sub>N<sub>5</sub>O.2HCl</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1032350-13-2
References:
References Yan L, AACR Annual Meeting 2009: Abstract Number: DDT01-1. Hirai H, et al. Mol Cancer Therapy, 2010, 9(7), 1956-1967. Cheng Y, et al, Cancer Res, 2011, 71(7), 2654-2663. WO2008070016 (A2)

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