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BIRB 796

BIRB 796

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Product Code: 3066
Availability: In Stock
$335.00
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BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.

Chemical Name: 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea

Inhibitors MAPK p38 MAPK BIRB 796 285983-48-4
Biological Activity:
Biological Activity BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.
Technical Data:
M.W. 527.66
Formula: C<sub>31</sub>H<sub>37</sub>N<sub>5</sub>O<sub>3</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 285983-48-4
References:
References Pargellis C, et al. Nat Struct Biol, 2002, 9(4), 268-272. Regan J, et al. J Med Chem, 2002, 45(14), 2994-3008. Kuma Y, et al. J Biol Chem, 2005, 280(20), 19472-19479. Yasui H, et al. Br J Haematol, 2007, 136(3), 414-423. Dietrich J, et al. Bioorg Med Chem. 2010, 18(15), 5738-5748. Regan J, et al. J Med Chem, 2003, 46(22), 4676-4686.

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