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SB203580

SB203580

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Product Code: 3263
Availability: In Stock
$185.00
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SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM.

Chemical Name:
4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine

Inhibitors MAPK p38 MAPK SB203580 152121-47-6
Biological Activity:
Biological Activity SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM.
Technical Data:
M.W. 377.43
Formula: C<sub>21</sub>H<sub>16</sub>FN<sub>3</sub>OS
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 152121-47-6
References:
References Ferdinand V. Lali, et al. J Biol Chem, 2000, 275(10), 7395-402. Birkenkamp KU, et al. Br J Pharmacol, 2000, 131(1): 99-107. Zhang H, et al. Apoptosis, 2011 Barancik M, et al. J Cardiovasc Pharmacol, 2000, 35(3), 474-83. Jin N, et al. Int Immunopharmacol, 2011, 11(9):1319-26.

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