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Dabrafenib

Dabrafenib

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Product Code: 3106
Availability: In Stock
$158.00
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Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Phase 3.

Chemical Name

N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide

Inhibitors MAPK Raf Dabrafenib 1195765-45-7
Biological Activity:
Biological Activity Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Phase 3.
Technical Data:
M.W. 519.56
Formula: C<sub>23</sub>H<sub>20</sub>F<sub>3</sub>N<sub>5</sub>O<sub>2</sub>S<sub>2</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1195765-45-7
References:
References Sylvie Laquerre, et al. 2009, EORTC International Conference. Abst B88. Greger JG, et al. Mol Cancer Ther, 2012, 11(4), 909-920.

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