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YM155

YM155

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Product Code: 3178
Availability: In Stock
$146.00
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YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. Phase 1/2.

Chemical Name:
Chemical Name 1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1)
 

Inhibitors Apoptosis Survivin YM155 781661-94-7
Biological Activity:
Biological Activity YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. Phase 1/2.
Technical Data:
M.W. 443.29
Formula: C<sub>20</sub>H<sub>19</sub>BrN<sub>4</sub>O<sub>3</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 781661-94-7
References:
References Nakahara T, et al. Cancer Res, 2007, 67(17), 8014-8021. Iwasa T, et al. Clin Cancer Res, 2008, 14(20), 6496-6504.

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