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R788 (Fostamatinib) Disodium

R788 (Fostamatinib) Disodium

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Product Code: 3294
Availability: In Stock
$398.00
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R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 2.

Chemical Name 2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, sodium salt (1:2)

Inhibitors Angiogenesis Syk R788 (Fostamatinib) disodium 1025687-58-4
Biological Activity:
Biological Activity R788 (Fostamatinib) disodium, a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 2.
Technical Data:
M.W. 624.42
Formula: <p>C<sub>23</sub>H<sub>24</sub>FN<sub>6</sub>O<sub>9</sub>P.2Na</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1025687-58-4
References:
References Braselmann S, et al. J Pharmacol Exp Ther, 2006, 319(3), 998-1008. Chen L, et al. Blood, 2008, 111(4), 2230-2237. Suljagic M, et al. Blood, 2010, 116(23), 4894-4905.

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