R406

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Product Code: 3292
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R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 2.

Chemical Name 6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one benzenesulfonate

Biological Activity:
Biological Activity	R406 is a potent Syk inhibitor with IC50 of 41 nM, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 2.
Technical Data:
M.W.	628.63
Formula:	<p>C<sub>22</sub>H<sub>23</sub>FN<sub>6</sub>O<sub>5</sub>.C<sub>6</sub>H<sub>6</sub>O<sub>3</sub>S</p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	841290-81-1
References:
References	Braselmann S, et al. J Pharmacol Exp Ther, 2006, 319(3), 998-1008. Quiroga MP, et al. Blood, 2009, 114(5), 1029-1037. Lhermusier T, et al. J Thromb Haemost, 2011, 9(10), 2067-2076. Zhu Y, et al. Toxicol Appl Pharmacol, 2007, 221(3), 268-277.

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