Bosutinib

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Product Code: 3076
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Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.

Chemical Name 4-(2,4-dichloro-5-methoxyphenylamino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile

Biological Activity:
Biological Activity	Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.
Technical Data:
M.W.	530.45
Formula:	<p>C<sub>26</sub>H<sub>29</sub>Cl<sub>2</sub>N<sub>5</sub>O<sub>3</sub></p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	380843-75-4
References:
References	Boschelli DH, et al. J Med Chem, 2001, 44(23), 3965-3977. Golas JM, et al. Cancer Res, 2003, 63(2), 375-381. Vultur A, et al. Mol Cancer Ther, 2008, 7(5), 1185-1194. Golas JM, et al. Cancer Res, 2005, 65(12), 5358-5364. Redaelli S, et al. Leukemia, 2010, 24(6), 1223-1227. Sakuma Y, et al. Oncol Rep, 2011, 25(3), 661-667.

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