Plinabulin

Plinabulin

Product Code: 3304
Availability: In Stock
$713.00
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Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 2.

Chemical Name: (3Z,6Z)-3-benzylidene-6-((5-tert-butyl-1H-imidazol-4-yl)methylene)piperazine-2,5-dione

 

Biological Activity:
Biological Activity Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 2.
Technical Data:
M.W. 336.39
Formula: <p>C<sub>19</sub>H<sub>20</sub>N<sub>4</sub>O<sub>2</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 714272-27-2
References:
References Nicholson B, et al. Anticancer Drugs, 2006, 17(1), 25-31. Singh AV, et al. Blood, 2011, 117(21), 5692-5700. Bertelsen LB, et al. Int J Radiat Biol, 2011, 87(11), 1126-1134.

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