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Tandutinib

Tandutinib

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Product Code: 3231
Availability: In Stock
$58.00
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Tandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 1/2.

Chemical Name:
N-(4-isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-carboxamide

Inhibitors Angiogenesis FLT3 Tandutinib 387867-13-2
Biological Activity:
Biological Activity Tandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. Phase 1/2.
Technical Data:
M.W. 562.7
Formula: C<sub>31</sub>H<sub>42</sub>N<sub>6</sub>O<sub>4</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 387867-13-2
References:
References Kelly LM, et al. Cancer Cell, 2002, 1(5), 421-432. Griswold IJ, et al. Blood, 2004, 104(9), 2912-2918. Schittenhelm MM, et al. Cell Cycle, 2009, 8(16), 2621-2630.

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