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Quizartinib

Quizartinib

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Product Code: 3295
Availability: In Stock
$461.00
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Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 1/2.

Chemical Name Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]-

Inhibitors Angiogenesis FLT3 Quizartinib (AC220) 950769-58-1
Biological Activity:
Biological Activity Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 1/2.
Technical Data:
M.W. 560.67
Formula: <p>C<sub>29</sub>H<sub>32</sub>N<sub>6</sub>O<sub>4</sub>S</p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 950769-58-1
References:
References Zarrinkar PP, et al. Blood, 2009, 114(14), 2984-2992.

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