Dovitinib

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Product Code: 3122
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Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2. Phase 4.

Chemical Name:

Propanoic acid, 2-hydroxy-, compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone

Biological Activity:
Biological Activity	Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.
Technical Data:
M.W.	572.59
Formula:	C<sub>21</sub>H<sub>21</sub>FN<sub>6</sub>O.2C<sub>3</sub>H<sub>6</sub>O<sub>3</sub>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	852433-84-2
References:
References	Trudel S, et al. Blood. 2005, 105(7), 2941-2948. Huynh H, et al. J Hepatol. 2012, 56(3), 595-601. Lee SH, et al. Clin Cancer Res. 2005, 11(10), 3633-3641. Azab AK, et al. Clin Cancer Res, 2011, 17(13), 4389-4399. Trudel S, et al. Blood, 2005, 105(7), 2941-2948

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