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Sunitinib Malate

Sunitinib Malate

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Product Code: 3240
Availability: In Stock
$180.00
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Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Chemical Name:
(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide ,(S)-2-hydroxysuccinic acid

Inhibitors Protein Tyrosine Kinase PDGFR Sunitinib Malate 341031-54-7
Biological Activity:
Biological Activity Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.
Technical Data:
M.W. 532.56
Formula: C<sub>22</sub>H<sub>27</sub>FN<sub>4</sub>O<sub>2</sub>.C<sub>4</sub>H<sub>6</sub>O<sub>5</sub>
Solubility: DBSO
Purity: 98%
Storage: -20℃
CAS No: 341031-54-7
References:
References Sun L, et al. J Med Chem, 2003, 46(7), 1116-1119. Mendel DB, et al. Clin Cancer Res, 2003, 9(1), 327-337. O'Farrell AM, et al. Blood, 2003, 101(9), 3597-3605. Abrams TJ, et al. Mol Cancer Ther, 2003, 2(10), 1011-1021. Yee KW, et al. Blood, 2004, 104(13), 4202-4209. Ikezoe T, et al. Mol Cancer Ther, 2006, 5(10), 2522-2530.

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