BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2.
Chemical Name N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
Biological Activity: |
Biological Activity |
BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases. Phase 1/2. |
Technical Data: |
M.W. |
512.89 |
Formula: |
<p>C<sub>25</sub>H<sub>19</sub>ClF<sub>2</sub>N<sub>4</sub>O<sub>4</sub></p> |
Solubility: |
DMSO |
Purity: |
98% |
Storage: |
-20℃ |
CAS No: |
1025720-94-8 |
References: |
References |
Schroeder GM, et al. J Med Chem, 2009, 52(5), 1251-1254.
Dai Y, et al. Mol Cancer Ther, 2010, 9(6), 1554-1561.
Dai Y, et al. Clin Exp Metastasis, 2012, 29, 253-261.
Kim KS, et al. J Med Chem, 2008, 51(17), 5330-5341. |